Finding and seeing things that nobody has ever seen before: Meet Alexandra Klein

Alexandra Klein (@aexolowski), Max Planck Insitute of Neurobiology, is taking part in Soapbox Science Munich on 1 June 2019 with the talk:An Anxious Island in the Brain – Die Ängstliche Insel des Gehirns“ 

 

 

 

Soapbox Science Munich: Did you choose a scientific career or did the scientific career choose you?

Alexandra Klein: It was definitely the second one – when I started my Bachelor in Biology, honestly, I had no idea what it means to be a “scientist”. But I got so excited about neuroscience in my last Bachelor years, so I decided I want to learn more about it and do a Master degree in neuroscience. And after finishing my Master, it was just clear for me that I wanted to continue doing a PhD – it was the logical next step, that I haven’t regretted so far!

 

SSM:What’s your favourite daily scientific superhero power?

AK: There are several: During my PhD, I became “Multitasking Woman”, “Not getting frustrated Girl”, and also “Mouse Poop Cleaning Lady”.

 

SSM: What is the most exciting aspect of your research?

AK: Finding and seeing things that nobody has ever seen before. Plus I am basically paid for being curious.

 

SSM: If you are stranded on a desert island: what scientific equipment would you bring?

  • Parafilm (can be used for everything, wrapping the other half of a coconut, attaching two things with each other – probably also building a boat…)
  • some of my mice (for company)
  • a Fold Scope (tiny paper microscope with optical quality similar to my lab microscope) to explore the island’s biology (as I probably will have a lot of free time).

 

SSM: What challenges do you encounter in science?

AK: One of my major problems in science is that I feel if you want to be a successful scientist, you have to focus your complete life onto your research. There is no room for anything besides science. And I actually like also doing different things that don’t include the lab.

 

SSM: What motivates you to give a talk in Soapbox science?

AK: There are several reasons: First, I really enjoy talking about my research, because I actually like what I am doing. Further, I find it is super important to show people who are not in science that what we are doing every day in the lab is really interesting and relevant – and we are not only wasting tax payers money. Plus, especially as I am working with animals, I think it’s extremely important to be honest and open about these experiments and answer also inconvenient questions that people might have – this way, we could maybe help people understanding this issue better and thus improve the public perception of animal experiments. Finally, I want to use the chance to speak at an event like Soapbox Science to demonstrate that being a good scientist does not depend on your gender.

 

SSM: What can we do to attract more women to STEM fields?

AK: I think it is still a major problem in academic science that there are actually many female scientists, but hardly any in leading positions. I would guess that one reason is that if you want to have a family, you will have to take a break from your career at some point, and the longer the break, the worse your chances are to get back onto your career path. Personally, I would think that supporting public childcare and better possibilities to combine kids and career would be a good and important starting point. Further, events like Soapbox Science are more than crucial to inspire young women to think about a career in the STEM field!

 

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There is always something new to learn: Meet Maria Kahlert

Maria Kahlert is an Associate Professor in biology with specialisation in ecology. Her research focuses on freshwater benthic algae; their biodiversity, how they are regulated by environmental factors, and how they can be used as biomonitors in lakes and streams. Maria Kahlert will take part in the Soapbox Science event in Uppsala on 25 May. She will talk about “Diatoms – microscopic small algae showing water quality and more”.

 

 

SS: How did you get to your current position?

I was called up and offered my current position by a colleague who met me in a joint project, where I probably did a good job.

 

SS: What, or who, inspired you to get a career in science?

Mainly, nature inspired me first: especially all water fauna. Raising frogs was an annual task. Then, Bernhard Grzimek, his books and documentaries and presence in TV was a great inspiration, especially actually his “Grzimeks Tierleben. Enzyklopädie des Tierreichs”.

 

SS: What is the most fascinating aspect of your research/work?

There is always something new to learn and understand. And it is not ending. And it is quite free: You can choose (more or less) what you want to focus on!

 

SS: What attracted you to Soapbox Science in the first place?

I think we scientists communicate too little with the people who actually pay our work. They have a right to ask questions, and to understand, but have very seldom a low-threshold possibility for it.

 

SS: Sum up in one word your expectations for the day

Communication.

 

SS: If you could change one thing about the scientific culture right now, what would it be?

The “third task”, i.e. communication of science to the public, should receive more funding and more impact when a researcher’s work is judged, and when grants and money are distributed. Right now, all focus is on scientific publications, excellence and high impact factors, but usually the “excellent” researchers have no time for the details, like both scientific details in the everyday work, and details about direct communication with the public. There is a need for us “everyday researchers”, but it is not easy to get paid for this.

 

SS: What would be your top recommendation to a woman studying for a PhD and considering pursuing a career in academia?

  1. Get a mentor, or similar, who is a kind, established, excellent male senior scientist with a large network and communicative skills who wants the best for you, and get help from him.
  2. Cherish your contacts, you never know where people end up. A large network is important and in particular my more informal contacts have often helped me see new possibilities and to take part in the research. Alone is weak. Large research groups are good for learning and “being included” but you must also establish your own ideas and this is easier in smaller groups, and after changing to a new group.

 

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That time I tried to discuss science with shoppers: Meet Rebeca Gonzalez Suarez

Rebeca Gonzalez Suarez is a Spanish particle physicist that works at Uppsala University in Sweden where she teaches physics in the Department of Engineering Sciences. Now a member of the ATLAS Collaboration at the Large Hadron Collider (LHC) since 2018, she started her career in the CMS Collaboration (2006-2018). A Higgs boson and top quark expert, today she keeps trying to find answers to long standing questions in the field searching for new phenomena at the LHC. At the Soapbox Science event in Uppsala on 25 May you can follow her on a guided tour to the subatomic world, visit the Higgs boson and the rest of the elementary particles, and plan a trip to the dark side.

 

 

By Rebeca Gonzalez Suarez

 

I am a particle physicist and my research involves investigating what comes out of high-energy proton-proton collisions at the Large Hadron Collider at CERN. We do this to learn more about elementary particles, those you cannot break down into smaller pieces. I have been lucky to be a part of the group of people who discovered the Higgs boson in 2012 (and I have a PhD thesis to show for it) and I have studied, among other things, the heaviest particle that we know of, the top quark.

Since last autumn, my research is funded by the Swedish Research Council, and I teach physics at Uppsala University, but before coming to Sweden, I spent ten years based at CERN, the biggest particle physics laboratory in the world. CERN is located in the French-Swiss border, very close to the city of Geneva, where I used to live.

I am a woman in science and I come from an underprivileged background. I did have a lot of privilege anyway compared to most people (and luck!), and I’m aware of it, but I still could see first-hand how opportunities do not come in the same way for everybody, and that hard work can only get you so far. So, because I want to make science more inclusive, and I know that representation matters, I take outreach very seriously. And I like outreach most of all because it can be quite fun and sometimes you get to do very cool experiments with the excuse of introducing science to the people that actually pay for it.

I have done a few things in the last years, and I have had a lot of fun. Sometimes I stressed about organization before and during the events, but it usually turned out fine, and worth the effort at the end.

This is about the one time when it was not. In September 2015, I participated for the second time in an event for the “night of the researchers” in Geneva. The goal for this event was to bring science to the regular lives of people by setting scientists free inside a mall, a shopping mall. The premise of the plan was good, I think it cannot be bad to get some science thrown at you, and this is also why I signed up for Soapbox Science. The execution of the plan however could have been better.

I was assigned to a big chain store shop that sells a bit of everything: electronics, books, and gadgets of all sorts. And in particular, my activity was to happen in the area of the TVs. This was 2015 and curved TVs were omnipresent. We have brought to the TV section a very cool feature: a colleague of mine was to go down 100 meters underground to one of the experimental caverns with a camera to give us a virtual visit, assisted by two more colleagues in the control room, and I was going to host from the shop. The visit was to be broadcasted in one of the huge curved TVs on sale. This was to be done in slots of 15 minutes at certain times agreed with the experiment beforehand. In between visits we had a little quiz with simple questions to keep the audience entertained.

This kind of virtual visit is a fantastic opportunity for people that cannot travel physically to CERN to go underground and see what kind of experiments we do with some detail. These visits take place at moments in which the LHC has stopped operation, even for a few days, and sometimes no other kind of visits are allowed. The guides can get very close to the big detectors and show not only their very large size, but also can focus on details that are not easy to show in regular visits. These visits are really quite something, I have done a few myself, mostly for high schools, and I can only recommend them.

The author, guiding a virtual visit to the CMS experiment in 2016

However, the TV area was in a deep corner of the shop, an area full of TVs well outside any natural flow of people. Somehow nobody was outside advertising our virtual visit, and nobody announced it using the speaker system of the shop, so in fact, nobody really knew we were there. We were two people in person in the shop to discuss science and my colleagues on-site.

After setting up our things, we quickly realized there was not a lot of people coming. We had to wait a few minutes before the first clients passed by there and when they did, there were usually 1, maximum 2 people at a time, and they clearly mistrusted out intentions. They were not aware that there was a science outreach event going on and they were perceiving us with high levels of suspicion. We tried to make contact with them and it was very hard, they did not want to be bothered and most of them ended up chased away from the TV section of the shop.

It took a while before the first shopper came to us, and to our astonishment, we got asked about curved TVs, comparison of TV performances, and prices. Eventually, we managed to attract one person or two to our stand and the first visit had some audience. I think the idea was good, and the connection worked very well. The people in the experimental site were not to be blamed by the lack of success, they did the best possible with the situation. But we had fixed time-slots for those visits to the cavern, and they were never advertised. In the middle of the visits, the shop would chant loudly its offers by megaphone, the visits were never announced.

We had t-shirts to give away but people would just hear from other people we were giving free t-shirts inside, so they would come in, get a t-shirt, get out. The only thing that worked to keep engagement was other people: I had two friends visiting me, and when they came, they attracted shoppers. A colleague also passed by and was of course interested, and that made 3 more people curious. Seeing other people coming to us made people come as well. Much like a restaurant that is empty scares away new customers.

So this was a story of failed outreach, but it was still ok, because we did discuss science with some interested customers, and we learned something. Not only about TVs, but also about what works and does not for engaging the public.

 

 

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What is there to know about pig parasites?: Meet Emelie Pettersson

Emelie Pettersson is a veterinarian and a PhD student at the National Veterinary Institute and the Swedish University of Agricultural Sciences. After graduating with a veterinary degree from the University of Melbourne, Australia in 2008 she spent almost nine years working in mainly small animal emergency and critical care medicine, both in Australia and in Sweden. With a desire to eventually work in the field of veterinary public health, Emelie did a Master of Science degree in International Animal Health through the University of Edinburgh, parallel to her clinical work, and graduated in 2014. In 2017, she started a PhD in veterinary parasitology and the career path took a new turn, from the emergency room with dogs and cats to pig farms and the laboratory, investigating the parasites of pigs.

Emelie Pettersson will take part in the Soapbox Science event in Uppsala on 25 May. She will talk about “Must improved pig welfare lead to more parasites?

 

 

 

By Emelie Pettersson

 

My topic for Soapbox Science 2019

My topic will be the parasites of pigs. I will first give the audience a little brief introduction to the life of the pig parasites and talk about how advanced some of them are in the way they live of their hosts. Secondly, I will talk about the way we keep Swedish pigs and how that may influence their parasites. Sweden has stringent animal welfare laws and aim to allow pigs to live in as natural housing conditions as possible, especially when compared to many other countries. Unfortunately, parasites may also thrive in these more natural housing environments and what I am looking at in my PhD project is if better animal welfare also results in more parasites?

 

What is there to know about pig parasites?

Lots of course! Pigs are hosts to several parasites and some of the most common ones are the pig roundworm, the nodular worm and the whipworm. Some of these parasites have quite fascinating life cycles. For example, the pig roundworm called Ascaris suum. It is a large, whitish worm that resemble thick spaghetti. The adult female worm can be as long as 40 cm and it lives in the small intestine of the pig. Pigs become infected when they ingest parasite eggs, excreted in the faeces by other infected pigs, from the environment. Pigs being coprophagic (i.e. the eat faeces) run a large risk of ingesting parasite eggs if these are present in the environment. Once the eggs are ingested, they hatch in the large intestine of the pig and the little larvae that have developed inside the eggs, escape. The larvae now start to migrate through the body of the pig. Initially they penetrate through the intestinal wall to reach the bloodstream. Here they just follow the blood flow and after a day or two they end up in the liver. While trooping through the liver these larvae obviously do some damage and they will cause inflammation and small bleeds. This is damage that the body will heal, and just as with other healing wounds, small white scars will form. The scars are called “white spots” or “milk spots”, as that is what they look like. The scars do not affect the liver or the pig itself but if they are found at slaughter, the liver is considered unfit for consumption and is condemned.

 

A few days after passing through the liver, the migrating larvae come to the lungs where they cause similar damage – bleedings and emphysema. This can obviously affect the pig’s ability to breath and the animals may develop laboured breathing and a cough. The damage caused may also predispose to other infections by bacteria or viruses that can take advantage of an already damaged lung. The larvae will eventually continue their journey into the windpipe of the pig where they get coughed up and swallowed, and suddenly they are back in the gastrointestinal tract again. Once back in the small intestine of the pig they either will be expelled and hence cleared from the host or they will stay on and develop into adult worms. New adult worms can reproduce and produce thousands of eggs that are excreted with the pig faeces into the environment. If the conditions in the environment are right and its warm and humid enough, these eggs will embryonate, which means they become infective and are then ready to infect new pigs that accidently eat them. A very elaborate life cycle for a simple parasite! Once in the small intestine these large adult worms may impact the pig’s ability to utilise their feed, to grow and to thrive. Parasite infections may hence influence both the welfare of the pig as well as productivity for the pig farmer. Many of the other gastrointestinal parasites of pigs may also influence their growth but in general pigs do not develop severe clinical illness from these parasites.

 

Parasite eggs that are shed from infected pigs survive well in the environment if the conditions are right. Eggs from the pig roundworm can survive for more than 15 years in the environment! The eggs are thick walled and resistant to most cleaning agents and disinfectants. This is also true for other parasite eggs from pigs and it is hence difficult to get rid of parasites from a stable.

 

What is different with Swedish housing conditions for pigs?

Sweden is thankfully a country with stringent animal welfare laws that were implemented in the 1980’s. For example, pigs are always to be kept loose. In many other countries, even in some of our Nordic neighbours, sows are fixated during large parts of their lives. Loose housing increases the likelihood of faecal contact which in turn could increase the chance of becoming infected with parasites. In Sweden a maximum of 30 % of the pen floor can be slatted, and farmers must provide some sort of bedding material for the pigs. Since parasite eggs survive well when it is warm (but not too warm) and humid, solid floors and bedding material can provide a much better environment for egg survival compared to bare slatted floors. It has been hypothesized that these examples of more natural housing conditions may increase the parasite load in a pig stable. The national parasite status of pigs in Sweden has not been investigated since the more stringent animal welfare laws were implemented and one thing I am investigating in my PhD project is if good animal welfare also means more parasites? Do Swedish pigs have more parasites now compared to when sows were fixated or when larger parts (if not all) of the floor was slatted?

 

What about drugs used to kill parasites?

Since the parasites are difficult to get rid of by cleaning and they usually do not cause severe disease in pigs, the aim is not to eradicate them from a pig herd. Instead the aim is to keep them at a low level where they do not really do any harm to the pigs and where productivity is not affected. Good hygiene is essential to achieve this. Also, the use of anthelmintic drugs or “de-wormers” are used frequently. De-worming drugs are often used routinely without farmers knowing if they need to use them or not, since the parasite status of a herd very rarely is known. Overuse of drugs, that may not be necessary in the first place, may favour the development of drug resistance. Parasites of other species such as horses and sheep have developed resistance to anthelmintic drugs, and it is known that pig parasites in other countries have done the same. So, another thing I am investigating in this project is if Swedish pig parasites also are becoming resistant to antiparasitic drugs.

 

As a little side note:

The pig roundworm, Ascaris suum, is very closely related (there is even discussion that it may even be the same parasite) to the roundworm that infect humans (Ascaris lumbricoides). The human roundworm is included in the so-called soil-transmitted helminthiasis. This is a group of four different gastrointestinal worms that infect up to 1.4 billion people around the globe and is considered a neglected tropical disease, causing large suffering mainly in children.

 

See you all on the 25th of May in Uppsala!

I am very grateful I have been selected to speak at the soapbox science in Uppsala this year. I think the idea of promoting and highlighting women in science is fantastic and I hope that the audience in Uppsala will find my talk interesting on the 25th of May.

 

 

 

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Look where curious got you: Meet Karin Steffen

Karin Steffen, is a doctoral student at Uppsala University. She has a background in biology from Albert-Ludwigs University in Freiburg, Germany and Uppsala University, Sweden. For her doctoral studies, she investigates natural product diversity in a deep-sea sponge. To this end, Karin uses different “-omics” (genomics and metabolomcis) and explores computational tools to integrate big data. Karin Steffen will take part in the Soapbox Science event in Uppsala on 25 May. She will talk about “Do ancient animals hold future drugs?

 

 

By Karin Steffen

I genuinely believe I have one of the best scientific jobs possible!

My job is a paid education, and allows me to be out on the sea for field work, to work with the latest high-end technologies in the lab for data collection and it stimulates me to develop computational and analytical skills. On top of that, it comes with recurring opportunities to be awarded travel stipends and reach out with my work on conferences all over the world.

My name is Karin and I am a PhD student in pharmacognosy.

How does this this go together and what does it actually mean?

Pharmacognosy is the study of natural products. That is, chemical compounds with bioactivity that are found in nature. This is where the field work comes in. In order to get my samples, the research group I’m part of goes out by boat to find deep-sea marine animals called sponges (think: Spongebob Squarepants). While quite exhausting work at times, field work takes me to places of utter beauty that I hardly could access otherwise.

 

Left: At the Swedish West coast, the ROV (sampling robot) on board the research vessel Nereus. Right: Sampling in action: same place at 95 m depth, showing the metallic edge of the ROV with the net for collecting the white sponge, which is guarded by a squat lobster.

 

Getting back to the science: Bioactive chemical compounds are very interesting, as they have the potential to become future drugs. And indeed, finding “drugs” in nature is far more likely than from random synthetic chemical “libraries”, big collections of compounds to be tested.

In order to get to the chemistry in my sponges, I use mass spectrometry (instruments that are able to detect individual molecules. How mind-blowing is that?!??!?!?!) and genome sequencing (a.k.a. the stuff you otherwise hear in the news about! I get to do it!).

But with all these technologies come heaps and heaps of data. Thus, enter the final challenge: making sense of it. While overwhelming at first, to me, the data analysis is much like a treasure hunt. With my knowledge and hypotheses about the data, I get to unravel the mystery of the endless sheets of numbers, (hopefully) leading to the answers we were out after.

Let’s be real for a second: Science can be really frustrating when things don’t work out. Which they often don’t. But you have to remember that that is not a surprise. After all, as scientists, our job is to find out things nobody knows yet or develop methods nobody has tried out yet. But I think, when it the right dose, it reminds us that we’re fortunate to develop and discover new things. We scientists contribute to society, for instance with knowledge about new drugs and unknown organisms (did you know about sponges before?). Being able to grow as a scientist and at the same time make a difference for the future is my daily reward that I am thankful for.

 

 

 

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Surround yourself with a supportive network: Meet Jessica Brown

Jessica Brown is in her second year as a PhD student in the XM2 Metamaterials Centre of Doctoral Training at the University of Exeter, where she is working on a project on acoustic microfluidics and phononic crystals. Here she tells us how her passion for physical science led her to her current position and what inspires her to strive in her field. Hopefully you caught Jessica’s talk at Exeter’s 2018 Soapbox Science event on the 29th of September!

 

SS: How did you get to your current position?

JB: Funnily enough, it all started when I was offered a place on a Graduate Business Partner internship at Exeter University – I had been working in a shoe shop back home for a few months after I finished my MPhys Physics with Astrophysics degree (also at Exeter), during which I’d been applying unsuccessfully for graduate schemes and PhD positions, mostly in astrophysics. The University Career Zone rang me up to suggest that I apply for the internship to help me into graduate level employment, and I was offered the role. Our team’s project looked at how well taught undergraduate modules aligned with the University’s overall Education Strategy, and as part of that we met module leaders to discuss their module content, assessment and teaching. I actually ended up meeting my now-supervisor who runs the Natural Sciences course here, and after he found out I was a Physics graduate, he asked if I would be interested in a PhD project with him. I had always wanted to do a PhD but never really had a break, so I jumped at the opportunity! I feel like I’ve taken a big risk switching from astrophysics and joining the XM2 Metamaterials Centre of Doctoral Training – people tend to have more practical backgrounds like experimental physics or engineering, or something similar to their PhD project – but I’m learning so many new skills and now my research feels more relevant to the real world. Having said all this, I always find it funny to think about how I wouldn’t be here now if I hadn’t worked in that shoe shop!

 

SS: What, or who, inspired you to get a career in science?

JB: I had always had a strong interest in science from a young age, but it really boils down to my teachers at school. Towards the end of my time at primary school, I had the most inspiring science teacher who really instilled my love of physical science, so my (slightly meandering!) journey towards a physics PhD is almost certainly thanks to him. My love of astronomy in particular was motivated by my GCSE Physics teacher, who had a very engaging approach to the topic I eventually concentrated on at university. Meeting my supervisor as an intern was also really inspiring, especially seeing his enthusiasm for what is now my research – this convinced me to change directions, and now working with him and the wider research group is fantastic!

 

A snippet from Jessica’s day: Finite-element modelling of surface acoustic wave streaming using COMSOL Multiphysics.

SS: What is the most fascinating aspect of your research/work?

JB: I’m still fairly early on in my project, so I’ve been concentrating on computational simulation and modelling so far with a little experimental work. At the moment, I’m still trying to get up to speed with the field! I suppose what I’m most excited about is the number of directions in which we could possibly go with it – I’ve had a lot of time to read lots of interesting papers about potential applications, which include things like biomedical diagnosis. If my research could be used to help people with illnesses, that would be very fulfilling for me.

 

SS: What attracted you to Soapbox Science in the first place?

JB: I was pointed towards the scheme by a previous participant in the CDT who said it was a great experience – it looks like a great way to introduce the public to interesting science, while simultaneously promoting female scientists. I also feel it’s very easy to get bogged down in your research, so taking a step back to think about it from the point of view of someone without a scientific background is a useful exercise.

 

SS: Sum up in one word your expectations for the day

JB: Outreach.

 

SS: If you could change one thing about the scientific culture right now, what would it be?

JB: I feel that the world of science is extremely competitive, which can be a good thing in terms of making fast progress in research, but at the same time it can be quite a daunting world to enter – I’m only at the beginning of my career (possibly even before it!) and I worry sometimes about being able to make my mark on my field of research.

 

Jessica explaining her research to other XM2 post-graduate researchers.

SS: What would be your top recommendation to a woman studying for a PhD and considering pursuing a career in academia?

JB: I definitely recommend surrounding yourself with a supportive network of other scientists (both female and male) and sticking to your guns – “imposter syndrome” is real, and you always know more than you think you do!

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Interdisciplinary research gives you a unique set of skills: Meet Monika Bokori-Brown

Dr. Monika Bokori-Brown is a research fellow at the University of Exeter where she studies bacterial toxins. Here she tells us about her work, what inspires her most and why she decided to take part in Soapbox Science. You can come and hear Monika speak at Soapbox Science in Exeter on the 29th of September where you can hear about her most recent discoveries!

 

 

 

SS: How did you get to your current position?

MBB: The route to my current position has been rather unconventional. I studied Biology and English at degree level in Hungary, both of which worked to my advantage when I decided to move into scientific research in the UK. Having completed an MSc in Molecular Biology, I became a research scientist at Porton Down where, as part of the molecular team, I engineered botulinum neurotoxins for the treatment of chronic pain. Whilst I really enjoyed being part of this commercial-oriented, multi-disciplinary project, I quickly realized that if I wanted to progress my career in science I needed to get a PhD. This meant leaving my permanent position to become a student again! I did my PhD at Cambridge University where my research focused on the molecular and cell biology aspects of a mitochondrial disease that affects the nervous system. After this I took a postdoctoral research scientist position at a start-up biotech company in Cambridge before retracing my steps into the field of bacterial toxins 11 years ago when I became a Research Fellow at the University of Exeter. Over the past five years my research has developed at the interface between biology and physics, using novel approaches to understand the biophysical and molecular aspects of the interaction of bacterial toxins with the cell membrane. Moving into interdisciplinary research has given me a unique set of skills and has allowed me develop my own area of research. I hope to build upon my established knowledge and expertise over the next few years to become a leading independent researcher.

 

SS: What, or who, inspired you to get a career in science?

MBB: Ever since I finished my undergraduate studies in Hungary I have been dreaming of becoming a research scientist. During my MSc studies I had an extremely supportive Professor as a mentor who inspired and motivated me to get a career in science. I strongly believe that encouragement and professional mentorship is critical to succeed in the highly competitive world of academic research. It is also very important to have a plan on what direction you want your research to take in the early stages of your career.

 

SS: What is the most fascinating aspect of your research/work?

Image of bacterial toxin-induced killing of human red blood cells. Dead cells appear with faint outlines of their membranes. Live cells have a distinctive halo around their edges.

MBB: Bacterial toxins tend to have a bad reputation and I want to show people that they also have a good side, helping us to develop novel therapeutics to combat serious animal and human diseases. I particularly enjoy the interdisciplinary aspect of my research, collaborating with many talented researchers whose skills complement mine. In the longer term, I hope that my interdisciplinary research will lead to new approaches to controlling bacterial infections caused by toxins. Development of novel therapeutics to fight bacterial infections is critical and timely, given the increasing incidence of antimicrobial resistant bacterial infections worldwide.

 

Bacterial pore forming toxins are typically produced by bacteria as one protein, called a monomer. In this form they are relatively inactive. However, when the monomers reach their target in the cell membrane they quickly become active and self-assemble into mushroom-shaped pores that puncture holes in the cell membrane. Through the mushroom’s stalk, called the pore, small molecules leak out of the cell, causing cells to die.

 

One way to prevent bacterial infections caused by toxins is to produce toxoid vaccines, a type of vaccine that contains toxins made harmless by inactivation. Amino acid substitution is a good way to inactivate toxins. The image shows a bacterial toxin with amino acids important for its function marked in blue.

 

SS: What attracted you to Soapbox Science in the first place?

MBB: Scientists often stay in their own ‘bubble’ of research groups with few opportunities to interact with the public. Becoming a Soapbox Science speaker will give me a rare opportunity to engage with the public in an unconventional way to inspire the next generation of scientists. It will also allow me to increase the visibility of my research.

 

SS: Sum up in one word your expectations for the day

MBB: Rewarding

 

SS: If you could change one thing about the scientific culture right now, what would it be?

MBB: I have now reached a critical stage in my career where if I wanted to advance my career within academia I would have to move organisations to get onto the academic career ladder and give up the practical aspect of research I love so much. This is because the current academic structure offers very limited career progression and job security for postdoctoral researchers and does not encourage postdoctoral researchers to apply for academic positions within the same organisation, which would allow for career progression. The limited career progression and job security for postdoctoral researchers mean that they often decide to leave science, which is extremely wasteful given the cost of training PhD students. I strongly believe that more credit needs to be given to postdoctoral researchers who make significant contribution to the success of their academic supervisors in terms of securing funding. If I could change one thing about the scientific culture right now it would be the career structure for postdoctoral researchers within academia.

 

 

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How I got to study the rarest whales in our oceans: Meet Kirsten Thompson, marine scientist and mother of three

Kirsten Thompson is a marine mammal geneticist and Associate Research Fellow at the University of Exeter. Here she describes her fascinating journey into science and the challenges of her next step. You can come and meet Kirsten and hear her speak about her work with deep diving marine mammals at Soapbox Science in Exeter on the 22nd of September.

 

 

 

By Kirsten Thompson 

Beaked whales are an enigmatic group of mammals. They are medium-sized, deep diving oceanic whales that we know nothing about. There are 22 recognized species of beaked whale but only very few species have been studied or even observed alive. Many species have only been described in the past 50 years after becoming stranded on our coasts. My work has used samples from stranded animals, together with DNA-based methods and morphological analyses, to try to better understand the lives of these deep ocean whales. I have investigated genetic population structure and ecology, morphology and social organisation in Gray’s beaked whale – a species that lives in the Southern Hemisphere and is only very rarely seen alive. In researching this curious whale, we also uncovered the external appearance of a mystery species – the spadetoothed beaked whale – that was previously known from only three bone fragments. Amazing that there are still 5 m long mammals that live out in the deep ocean and are still a mystery to science.

 

How I became a whale biologist

My first inspiration, Shetland where I grew up

I grew up in Shetland and my childhood was spent running around in the wild studying the birds, seals, wild horses and digging around in rock pools. There is one high school in Shetland, overlooking the sea. At the weekends I spent my time working on a farm, riding horses and working with my dad on his boat. Shetland is an inspiring place, full of wilderness and extreme weather, it would be hard to grow up there and not have a relationship with wildlife. I studied zoology at the University of Glasgow and tried to get as much experience in every summer holiday. In 1990 I spent a summer as a deckhand on a Greenpeace ship ­– life at sea is fun, every day is different and driving huge powerful inflatables is a blast.

 

My first job after graduating was as a research assistant surveying for otters around Shetland. I wrote numerous letters to one of the most prominent mammal biologists, Professor Hans Kruuk, who I knew would be assessing the impacts of the Braer oil spill on the otters of Shetland. Eventually Professor Kruuk must have wondered who this crazy girl was that kept pestering him and telephoned me inviting me to join the survey. I worked as a research assistant on several field projects – radio tracking red squirrels and pine marten, surveying barnacle geese – before moving to the University of Oxford to work on badgers. Working as a biologist is a privilege – you are able to see some of the most beautiful species, up close in a way that only few people can.

 

Getting hooked on venturing out to sea, one of the research vessels I worked on early in my career

In Oxford I worked for the Wildlife Conservation Research Unit on several projects, ultimately leading me to work on marine mammals. I was offered a job on a research yacht and was hooked. I spent extensive periods at sea, sailing the waters of the Azores, Caribbean and the Mediterranean while researching sperm whales and other cetaceans – acoustic tracking, recording behaviour and using photoidentification to monitor individuals and populations, and analysing the data in Oxford. At that time, I had bought and rebuilt a narrow boat and lived on the Oxford Canal. Field work is fantastic because it is so varied. Sometimes we would track and follow a pod of sperm whales for 10 days and nights, film them underwater and record the intimacies of their lives. Other times we spent days ashore talking to local communities about our research and analysing data. I worked on many field projects at sea, with different focal species and different techniques – aerial surveys, photoidentification, behavioural observation.

 

I met my husband and within a couple of years we started a family and moved to New Zealand. I started a PhD at the University of Auckland, which I postponed to raise my boys. My return to work was part-time on a large humpback research project run by a colleague and friend at Auckland. I was lucky to be part of an active research group with marine mammal conservation projects running over the South Pacific. I contributed to data management, photo-identification analyses and later curation of one of the largest cetacean tissue collections in the world.

 

Another adventure, publishing!

My interest in genetics stemmed from working with many talented ecologists and geneticists – some of the scientists working in New Zealand are leaders in the field of conservation genetics so I took the opportunity to upskill. I enrolled in a Masters by Research part-time, got a student loan for fees, commuted, worked four part-time jobs, did homework with my boys, never missed a sports day and shared running our home with my husband. After publishing my first lead-author paper, I managed to get a university scholarship and some external funding. I listened carefully and learned from fantastic supervisors, collaborators and the highly skilled technician in our laboratory – and managed to get a First (top marks)! When we moved back to the UK, I carried on publishing our work and put together my PhD by Publication at the University of Exeter.

 

Now that I have my PhD, I am faced with the tricky task of trying to find funding for research or an appropriate postdoctoral position near where I live. It’s not easy. As scientists in an academic environment we apply to funding bodies to get money to pay for our research and for someone in my position, our salary. I am applying for Fellowships alongside working part-time as a consultant for Greenpeace Research Laboratories. I have a small grant to carry out more genomics work on Southern Hemisphere beaked whales, with collaborators in South Africa, Australia and New Zealand.

 

Soapbox Science is about women in science and it is about changing the outdated expectation in academia that professors are old men in white-coats that stay in the lab and waffle on about science in a way that no one else can understand. Social media – #kindnessinscience, #womeninscience #oceanoptimism – tells us that the times are changing. Let’s gently and respectfully change the paradigm of science and in doing so break the mould!

 

Three words for women seeking a career in science: listen, learn and persist.

 

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Using electrophysiology to study Alzheimer’s Disease: Meet Soraya Meftah

 

Soraya Meftah is a PhD Student based at the University of Exeter and Bristol, funded by the MRC GW4 Biomed DTP. Her current research focuses on early changes in connections between neurons in Alzheimer’s Disease. She does this using electrophysiology and multi-photon microscopy (measures electricity in the brain and looks at it using a really powerful laser beam!). Come and meet Soraya this Saturday at Exeter’s Soapbox Science event!

 

SS: How did you get to your current position?

SM: By many applications and a little luck! I was working at a pharmaceutical company in research and development and decided that I enjoyed and wanted to do research as a career. So I made the decision to apply for a PhD. I’d heard of the research happening here and at Bristol and decided that it would be a good fit for me and match up with the research I was doing at the time. So here I am! But it didn’t come easily, it took a lot of searching, a number of applications (and rejections) before I ended up with a few offers of where to go and decided that here would be the best fit.

 

SS: What, or who, inspired you to get a career in science?

SM: Well I’ve always enjoyed science. The fact that you can constantly be working at new and challenging things was always a draw. When I was younger, I was intrigued with the world around me and science always gave me new challenges and kept me interested. So I think that gave me the idea that I would like science. However, I think there have also been people in my life that have helped me along the way including a number of very encouraging supervisors that have supported and kept me going in science.

 

A neuron filled with a dye after recording

SS: What is the most fascinating aspect of your research/work?

SM: So my current and previous research has been on Alzheimer’s Disease. It’s a terrible disease that affects 850,000 people in the UK alone, and to be able to work at helping to understand and combat a disease like this is really rewarding. I guess the most fascinating part of my research is that I am helping to shape my area of research that will help the larger field of research and find out novel things that no one else has seen. Currently, I’m focussing on the way the connections in the brain in a model of Alzheimer’s Disease change and how they change prior to seeing any symptoms. I’ve seen some subtle changes that may hint at early alterations in these connections in Alzheimer’s Disease.

 

SS: What attracted you to Soapbox Science in the first place?

Giving a talk about some of my data

SM: Soapbox Science is something that encompasses a lot of aspects that I feel are important in science. Engagement with the public about science is important as we are at the end of the day serving the public. Scientific research would not be happening without the support of the public and we owe it to them to share what we know with them. Also, it’s fun to share what you have learnt about the world and people are interested in learning about what we do.

In addition, increasing the visibility of women in science and the struggles we face having a career in science is the only way we will change how things work. I couldn’t imagine having a career in anything else and so making it easier for women who want to stay in science without extra barriers being in the way is really important to me and for the future of science. Our thoughts and research are just as valuable and yet we are overlooked in multiple ways.

 

SS: Sum up in one word your expectations for the day

SM: Sciencitement!

 

Me with my electrophysiology rig in Exeter (ready to record some cells!)

SS: If you could change one thing about the scientific culture right now, what would it be?

SM: Job stability vs pressure to move. In science, or at least in my field, there isn’t always job availability at the end of your contract (usually short and fixed term of 2-3 years) and when that’s done if you haven’t managed to secure money then you’re looking at moving somewhere far away typically to get another job doing similar work.

 

SS: What would be your top recommendation to a woman studying for a PhD and considering pursuing a career in academia?

SM: Perseverance! It took me a while to get where I am currently, and I had to work hard but I think if you aim and be realistic with those aims you will get there.

 

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What it means to be a woman from an under privileged background in science: Meet Sariqa Wagley

Sariqa Wagley is a researcher at the University of Exeter in the Biosciences department where she works on bacterial pathogens affecting human health. Here she narrates her route through education, talks to us about the challenges facing women and those from underprivileged backgrounds in science, discloses her favourite bacteria and tells us what Soapbox Science means to her. You can come and meet Sariqa in Exeter on the 22nd of September when she gets on her soapbox in the centre of town!

 

 

 

What it means to be a woman from an under privileged background in science

By Sariqa Wagley

 

How did I get into science? Pull up a pew…

I am a Muslim Asian woman who grew up in Luton (Bedfordshire).  At high school I was one of the brightest students in the year and I enjoyed school thoroughly and finished with great GCSE results. I carried out voluntary work at the local hospital and it was then I knew I wanted to study health and disease in some form. Both my parents had limited access to education in India but understood that a good education would lead to good job prospects and more opportunities. They placed a heavy emphasis on education and schooling and pushed me and my siblings to go to university. However, being from a low income family this was not an easy task. The year I was to start university the government scrapped maintenance grants for those studying in higher education. My parents were against taking out student loans with a fear that I may not be able to pay it back and would be faced with a debt early in life. I realised that if I was going to go to university I was going to have to start earning money. I found a part time job in the final year of high school and started saving my money to help pay for university.  I went to the local sixth form college and I found myself struggling straight away to keep on top of my studies. I managed to scrape through my A-levels and got a place at Surrey University to study Medical Microbiology. I had to carry on working in the first year to help pay my way and again during the course I found myself struggling to stay on top of things.

When I finished my first year with a mere 50% overall I was totally disheartened and dismayed at my progress or lack of! I went to see my personal tutor and slumped in a chair in his office I remember listening to him go through some of my exam papers and tell me how I had failed to grasp the questions in my exam and answer them properly.  After a while, I think he must have felt sorry for me as he changed his tone and started asking me what I wanted to do and why was I at university. I told him about my interest in science, what motivated me about my course, I told him about my parents who pushed me to have the best education and that having a university degree was key to that. I told him I didn’t have much money and that I had a part time job working Wednesdays (the day students have free for extracurricular activities) and weekends. It was then he made some critical changes that pretty much changed how my career went.  He sent me on an extra tuition course aimed for foreign students and made me attend an essay writing course. He encouraged me to reduce my hours on my job and gave me some extra reading to do around my modules. I felt a little insulted and an incredible amount of shame thinking how could I possibly need all this extra help when I had been the top of my school only three years previous.  The feeling of being somewhere I didn’t belong was hitting me hard and being surrounded by top students, who seemed to know and have everything, I felt like the outsider.

A report by the Sutton Trust published in 2008 on ‘Increasing higher education participation amongst disadvantaged young people and schools in poor communities’ stated that 60,000 pupils (10% of the cohort) who at some point were among the top fifth performers in their school, still failed to enter higher education by the age of 19. Furthermore, 70% of 11-16 year olds from disadvantaged backgrounds said they would go into higher education, but the reality of students choosing to go to university was lower.  The main reasons for young people from disadvantaged backgrounds not continuing their further education was their need to start earning, avoid debt and they felt disillusioned with formal learning.  Furthermore, those in poorer families lacked the support from their peer groups and families and the aspirations were lower in how far they could go with their education.

Now many years later, it is easy for me to say I came through that second year at university with an overall 60%, which was a huge improvement. But in reality, I had to face some hard facts about whether I was suited for higher education and I had to take on board a lot of practical advice to change my circumstances which was not easy. I recognise those findings from the Sutton Report in my own experience and realise that had I not had the support of my tutor (Late Dr Tony Chamberlain) at Surrey University I would most probably have dropped out sometime in my second year.

In 2003, I carried out my industrial placement year at a government science lab called Cefas in Weymouth working on human pathogens which sealed my future as a microbiology scientist. The good news was I saved enough money from my industrial placement to ditch my part time job in my final year and so I could concentrate fully on my studies. I finished with a 2:1 degree in Medical Microbiology and was offered a PhD at Cefas for 4 years to carry out research in microbiology. Due to the struggles I had faced prior to and during my degree; graduating was a very proud moment for me.

 

Is it all plain sailing from here? Well….

I finished my PhD and came to work at the University of Exeter as a post doc. Here, I found the Black, Asian and Minority Ethnic (BAME) students make up 20% of the undergraduate student cohort (data for 2016) which is a smaller proportion of the UK cohort than other Russell Group universities. The number of staff from BAME groups in Biosciences where I am based is a low 8% in 2016/2017.  Recently, the University of Exeter came into the headlines, when a number of students were expelled following allegations of racism, sexism, and homophobia towards other students. Earlier this year, at Nottingham Trent University, a black student captured the moment on video when she was forced to hide in her dorm room while being subjected to a tirade of racist abuse from other students. Given the environment that students and sometimes staff encounter on higher education campuses the low uptake numbers of BAME students and staff at University of Exeter does not surprise me. I have accepted that getting into and surviving in academia for people of BAME and/or from disadvantaged backgrounds is still not an easy task and more needs to be done to change the environment that students and staff are being recruited into.

2016/2017 data for academic career progression pipelines in Biosciences (Exeter University)

Discrimination on higher education campuses is not limited to amongst the student body. There is a significant amount of inequality in career progression through academia which I had not been prepared for. At undergraduate level there are more females (63%) than males (37%) in Biosciences at the University of Exeter. As the academic progresses through their career trajectory the number of males and females are even until they reach a tenure position i.e. a permanent position with a university.  At this point the balance shifts and the number of female staff drops dramatically and becomes male biased. The key question for me when I heard these facts were ‘what is happening to all these women and why are they dropping out?’

 

So why are women dropping out?

Some researchers are focusing on women’s choices to explain the number of women dropping out of the work force in STEM subjects. Unfortunate terms such as the ‘Opt-Out’ idea coined by the New York Times in 2003 suggests that some women in successful jobs once they reach around 30 – 40 years old decide to opt-out of their careers usually to spend more time with their families. These women who ‘Opt-Out’ state that it was not due to discrimination or other barriers in the workplace, but because it was their choice to do so and that they choose different things to men.  I do not agree with this ill-termed ‘Opt-Out’ idea as it has not been very easy for me to get to where I am in my career and as an early career researcher hearing that independent educated women chose to drop out or leave academia is hard to grasp.  The problem with the ‘Opt-Out’ idea is that the onus or blame for the low levels of women in higher positions in the workplace is put solely on women and the root of these patterns remains ignored.

Breaking down gender stereotypes in academia and changing structural barriers that face women such as policies around maternity and paternity leave, recruitment, promotion, leave taking and decision making within departments are all important factors that are or have been hindering women’s career progression. I also believe, that continued unconscious biases in academic culture are predisposing men for career success and leaving women in the side lines. These biases include ideas such as ‘working mums’ are not committed to their careers, or that women are too emotional, that women speak too softly, women who show high levels of emotional intelligence cannot be effective in leading, and ideas like ‘men are the born leaders’ and women are just seen as bossy when take charge.  These biases are exasperated by the high emphasis on winning and securing funding which can be a significant hindrance to both men and women in academia.  As a consequence women are missing out on good jobs with good salaries and long term the academic environment is losing a wide talent pool of female scientists that bring diversity in different thought process’ and research talent.

 

Who am I now and what am I doing in science?

It is has been over 10 years since I finished my university degree and I have been a research scientist at the University of Exeter since 2008. I work on understanding how bacteria cause disease in humans and what weapons they have to make us sick. By doing this research I can help make informed decisions about strategies for detection, prevention and cure of bacterial infections in humans. I have worked on a number of different bacteria that make people sick and my favourite is called Vibrio parahaemolyticus.  It causes gastroenteritis when people eat raw or under cooked shellfish that are contaminated with this bacterium.  In 2016, I won a significant BBSRC research grant to study this pathogen and I am now studying how V. parahaemolyticus enters a dormant or sleep-like state when faced with stressful conditions and how it reawakens from this sleep when those conditions around them become more favourable. This is a clever defence strategy that bacteria have to help them survive adverse conditions and environments.  I love my job as a researcher and enjoy making new discoveries and having an impact in the real world.  I get to work with top scientists from institutes such as Cefas, FDA, DSTL, Natural History Museum, and defence agencies in the USA.  I have been fortunate enough to travel (one of the perks of the job) and present my research to people all over the world including Europe, Thailand, USA, New Zealand and Australia. I am currently applying for fellowships which would secure me a permanent position in academia. I know I still have a long way to go before I will be truly satisfied I have made it in science. But if it had not been for my own personal determination, and encouragement from my parents and support from my tutor at university, I would not have been able to contribute to science and society in the way that I have.

 

What attracted me to Soapbox Science in the first place?

I believe that all young people should have a chance to enter higher education regardless of their background and gender or where they live.  At the University of Exeter, the Centre for Social Mobility is there to help support students from disadvantaged groups and realise their potential through higher education.  There is widening participation and access programmes that are geared to increasing uptake of BAME students and those from disadvantaged groups and I hope the University of Exeter can increase their targets in this area by using these programmes to maximise the best effects.  But to really encourage students from these backgrounds into STEM subjects requires people from those groups that have had some success to create a presence in society and break down existing stereotypes. Which is why I wanted to take part in Soapbox Science.  I wish I had had access to programmes like Soapbox Science when I was growing up or some scientist role models to aspire to. Soapbox Science is a fantastic initiative that supports female scientists all around the country and helps provide these much needed role models for young people who may be considering a career in the STEM subjects.  It is important to me that young people in the same situation that I was in, realise that a career in science is possible for them too.

 

References:

Report to the National Council for Educational Excellence, The Sutton Trust, 2008. https://extra.shu.ac.uk/higherfutures/digest/misc/report_suttontrust.pdf

Equality data at Exeter University http://www.exeter.ac.uk/staff/equality/equalitydata/

Exeter University expels students over racism row, The Guardian, 2011  https://www.theguardian.com/education/2018/may/01/exeter-university-expels-students-over-racism-row

Police arrest two 18-year-old men over racist chanting outside Nottingham Trent University student’s bedroom, The Telegraph, https://www.telegraph.co.uk/education/2018/03/08/police-arrest-two-18-year-old-men-racist-chanting-outside-nottingham/

Academic career progression pipelines in Biosciences http://lifesciences.exeter.ac.uk/athenaswan/

The Opt-Out Revolution, New York Times by Lisa Belkin, 2003. https://www.nytimes.com/2003/10/26/magazine/the-opt-out-revolution.html

 

 

 

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